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KMID : 0848120110360010007
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International Journal of Oral Biology
2011 Volume.36 No. 1 p.7 ~ p.11
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Antimicrobial Effects of Ursolic Acid against Mutans Streptococci Isolated from Koreans
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Kim Min-Jung
Kim Chun-Sung
Park Jae-Yoon
Lim Yun-Kyong
Park Soon-Nang
Ahn Sug-Joon
Jin Dong-Chun
Kim Tae-Hyung
Kook Joong-Ki
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Abstract
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Ursolic acid is a triterpenoid compound present in many plants. This study examined the antimicrobial activity of ursolic acid against mutans streptococci (MS) isolated from the Korean population. The antimicrobial activity was evaluated by the minimum inhibitory concentration (MIC) and time kill curves of MS. The cytotoxicity of ursolic acid against KB cells was tested using an MTT assay. The values of ursolic acid for Streptococcus mutans and Streptococcus sobrinus isolated from the Korean population were /ml and /ml, respectively. Ursolic acid had a bactericidal effect on S. mutans ATCC and S. sobrinus ATCC at > /ml) and /ml), respectively. Ursolic acid had no cytotoxic effect on KB cells at concentrations at which it exerted antimicrobial effects. The results suggest that ursolic acid can be used in the development of oral hygiene products for the prevention of dental caries.
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KEYWORD
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antimicrobial effect, Streptococcus mutans, Streptococcus sobrinus, ursolic acid
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